Greene is brought to Carson City for a prison transfer aboard the plane "the Jailbird". Unknown to the guards, the plane had been hijacked by its own prisoners, led by Cyrus "The Virus" Grissom. Greene was transported from a heavy security vehicle, with numerous restraints, causing a stir among the disguised convicts posing as guards. Parolee and ex-miltary hero Cameron Poe is mutually shocked by Greene's presence on the plane. His prison friend "Baby-O" is also disturbed by Greene's murders, identifying him as "the Marietta Mangler" and that his killings made "the Manson Family look like the Partridge Family."
Shortly after escaping Carson City, Grissom orders Nathan "Diamond Dog" Jones to release Greene, whom he considers a "national treasure", praising his crimes. Diamond Dog is visibly shaken by Greene's intimidating features. Later, Greene sits next to Poe, musing about fellow prisoner Billy Bedlam's mental behavior. A while later, Poe is forced to kill Bedlam, who became aware of Poe's status as a free man. Greene deduces the aftermath and discusses the semantics of murder and insanity, much to Poe's disgust.
When the Jailbird lands at Lerner Airfield, Greene separates himself from the other criminals and meets a girl playing by herself in an abandoned swimming pool. The girl invites him to play with her, but soon questions his unhealthy-looking appearance. When Greene explains there is no medicine for his condition, the girl invites him to sing "He's Got the Whole World in His Hands."
Later, when Grissom's plans to escape are foiled, he orders the Jailbird to take off, Greene having rejoined the other prisoners, carrying a doll resembling Ken, most likely given to him by the little girl, who is last seen waving goodbye to the plane.
When the Jailbird is forced to make a landing in Las Vegas, Greene is again singing merrily "He's Got the Whole World in His Hands" during the descent. The plane eventually crashes into the Sands Hotel and Casino, Greene evades capture by the police. He is last seen playing craps at a casino, wearing a jacket and enjoying a drink, feeling lucky and his appearance looking more healthy and sane.
Known as "The Marietta Mangler", Garland Greene is by all accounts the most dangerous convict in the movie (even more so than Cyrus "The Virus"), due to killing up to thirty people, and in very gruesome manners (he even wore a girl's head as a hat). Because of this, most of the other convicts (including Johnny 23 and Diamond Dog) are afraid of him (except for Cyrus, who actually admires him). He is shown to be intelligent, as he shown trying to deduce the reason for Billy Bedlam's anger. After Poe kills Bedlam, he tells Poe there is a difference between killing for necessity, and killing for pleasure. He describes his fellow convicts (aside from Poe and Baby-O) as "a bunch of idiots", which implies he wants nothing to do with them.